The lake is remote and thinly populated by peasant fishermen, the local residents are Bedouin camel and sheep herdsmen who are occasionally seen grazing their flocks on the sparse vegetation at the edge of the lake. There are an impressive variety of birds, mammals, and reptiles. More than 100 species of birds have been recorded: Wild duck, Egyptian geese, pelicans, herons, egrets and various species of hawks, kites, falcons and eagles will be among the birds seen. In most areas there are crocodile and monitor lizards, other types of wildlife include Dorcas gazelle, jackals, desert fox, and various smaller desert mammals.

Lake Nasser is a place where a small group of anglers have literally hundreds of square miles to themselves. Lake Nasser has arguably the best freshwater fishing in the world for both Nile perch and Tiger Fish. There are also several species of catfish; the legendary giant Vundu being the biggest. Two species of Tilapia also inhabit the lake and give a good account of themselves on a fly rod. All told there are some thirty two species of fish in the lake.